CATH Classification

Domain Context

CATH Clusters

Superfamily PLAT/LH2 domain
Functional Family Triacylglycerol lipase

Enzyme Information

3.1.1.3
Triacylglycerol lipase.
based on mapping to UniProt P54317
Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
-!- The pancreatic enzyme acts only on an ester-water interface; the outer ester links are preferentially hydrolyzed.
3.1.1.26
Galactolipase.
based on mapping to UniProt P54317
1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H(2)O = 3-beta-D- galactosyl-sn-glycerol + 2 carboxylates.
-!- Also acts on 2,3-di-O-acyl-1-O-(6-O-alpha-D-galactosyl-beta-D- galactosyl)-D-glycerol, and phosphatidylcholine and other phospholipids.

UniProtKB Entries (1)

P54317
LIPR2_HUMAN
Homo sapiens
Pancreatic lipase-related protein 2

PDB Structure

PDB 2OXE
External Links
Method X-RAY DIFFRACTION
Organism Spodoptera
Primary Citation
Structure of human pancreatic lipase-related protein 2 with the lid in an open conformation.
Eydoux, C., Spinelli, S., Davis, T.L., Walker, J.R., Seitova, A., Dhe-Paganon, S., De Caro, A., Cambillau, C., Carriere, F.
Biochemistry