CATH Classification

Domain Context

CATH Clusters

Superfamily Ricin (A Subunit), domain 2
Functional Family

Enzyme Information

3.2.2.22
rRNA N-glycosylase.
based on mapping to UniProt P84530
Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.
-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.

UniProtKB Entries (1)

P84530
RIP_LUFAC
Luffa acutangula
Ribosome-inactivating protein luffaculin 1

PDB Structure

PDB 2OQA
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
X-ray sequence and crystal structure of luffaculin 1, a novel type 1 ribosome-inactivating protein
Hou, X., Chen, M., Chen, L., Meehan, E.J., Xie, J., Huang, M.
Bmc Struct.Biol.