CATH Classification

Domain Context

CATH Clusters

Superfamily POLO box domain
Functional Family Serine/threonine-protein kinase PLK

Enzyme Information

2.7.11.21
Polo kinase.
based on mapping to UniProt P53350
ATP + a protein = ADP + a phosphoprotein.
-!- The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. -!- The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P30307
MPIP3_HUMAN
Homo sapiens
M-phase inducer phosphatase 3

PDB Structure

PDB 2OJX
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization.
Garcia-Alvarez, B., de Carcer, G., Ibanez, S., Bragado-Nilsson, E., Montoya, G.
Proc.Natl.Acad.Sci.Usa