CATH Classification

Domain Context

CATH Clusters

Superfamily Fumarase/aspartase (Central domain)
Functional Family Histidine ammonia-lyase

Enzyme Information

4.3.1.23
Tyrosine ammonia-lyase.
based on mapping to UniProt Q8GMG0
L-tyrosine = trans-p-hydroxycinnamate + ammonia.
-!- Member of the aromatic amino acid lyase family, other members of which are EC 4.3.1.3, EC 4.3.1.24 and EC 4.3.1.25. -!- Far more active with tyrosine than with phenylalanine as substrate, but the substrate specificity can be switched by mutation of a single amino acid (H89F) in the enzyme from the bacterium Rhodobacter sphaeroides. -!- Formerly EC 4.3.1.5.
5.4.3.6
Tyrosine 2,3-aminomutase.
based on mapping to UniProt Q8GMG0
L-tyrosine = 3-amino-3-(4-hydroxyphenyl)propanoate.

UniProtKB Entries (1)

Q8GMG0
TAM_STRGL
Streptomyces globisporus
MIO-dependent tyrosine 2,3-aminomutase

PDB Structure

PDB 2OHY
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The structure of L-tyrosine 2,3-aminomutase from the C-1027 enediyne antitumor antibiotic biosynthetic pathway
Christianson, C.V., Montavon, T.J., Van Lanen, S.G., Shen, B., Bruner, S.D.
Biochemistry