CATH Classification

Domain Context

CATH Clusters

Superfamily 7,8-dihydroneopterin aldolase (MptD)
Functional Family

Enzyme Information

4.1.2.25
Dihydroneopterin aldolase.
based on mapping to UniProt Q57851
7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde.
-!- The enzyme participates in folate (in bacteria, plants and fungi) and methanopterin (in archaea) biosynthesis. -!- The enzymes from the bacterium Escherichia coli and the plant Arabidopsis thaliana also catalyze the epimerisation of the 2' hydroxy-group (EC 5.1.99.8). -!- The enzyme from the bacterium Mycobacterium tuberculosis is trifunctional and also catalyzes EC 5.1.99.8 and EC 1.13.11.81. -!- The enzyme from the yeast Saccharomyces cerevisiae also catalyzes the two subsequent steps in the folate biosynthesis pathway - EC 2.7.6.3 and EC 2.5.1.15.

UniProtKB Entries (1)

Q57851
MPTD_METJA
Methanocaldococcus jannaschii DSM 2661
Dihydroneopterin aldolase

PDB Structure

PDB 2OGF
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of hypothetical protein MJ0408 from Methanococcus jannaschii
Ramagopal, U.A., Toro, R., Sauder, J.M., Burley, S.K., Almo, S.C.
To be Published