CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Tyrosine-protein kinase

Enzyme Information
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P06239
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC

UniProtKB Entries (1)

Homo sapiens
Tyrosine-protein kinase Lck

PDB Structure

External Links
Primary Citation
Discovery of Aminoquinazolines as Potent, Orally Bioavailable Inhibitors of Lck: Synthesis, SAR, and in Vivo Anti-Inflammatory Activity
DiMauro, E.F., Newcomb, J., Nunes, J.J., Bemis, J.E., Boucher, C., Buchanan, J.L., Buckner, W.H., Cee, V.J., Chai, L., Deak, H.L., Epstein, L.F., Faust, T., Gallant, P., Geuns-Meyer, S.D., Gore, A., Gu, Y., Henkle, B., Hodous, B.L., Hsieh, F., Huang, X., Kim, J.L., Lee, J.H., Martin, M.W., Masse, C.E., McGowan, D.C., Metz, D., Morgenstern, K.A., Oliveira-dos-Santos, A., Patel, V.F., Powers, D., Rose, P.E., Schneider, S., Tomlinson, S.A., Tudor, Y.Y., Turci, S.M., Welcher, A.A., White, R.D., Zhao, H., Zhu, L., Zhu, X.