CATH Classification

Domain Context

CATH Clusters

Superfamily Protein tyrosine phosphatase superfamily
Functional Family Tyrosine-protein phosphatase non-receptor type 12

Enzyme Information

3.1.3.48
Protein-tyrosine-phosphatase.
based on mapping to UniProt Q99952
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.

UniProtKB Entries (1)

Q99952
PTN18_HUMAN
Homo sapiens
Tyrosine-protein phosphatase non-receptor type 18

PDB Structure

PDB 2OC3
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Barr, A.J., Ugochukwu, E., Lee, W.H., King, O.N., Filippakopoulos, P., Alfano, I., Savitsky, P., Burgess-Brown, N.A., Muller, S., Knapp, S.
Cell(Cambridge,Mass.)