CATH Domain 2oa6A00
|1.10.600||Farnesyl Diphosphate Synthase|
|1.10.600.10||Farnesyl Diphosphate Synthase|
|Superfamily||Farnesyl Diphosphate Synthase|
based on mapping to UniProt Q9UR08
(2E,6E)-farnesyl diphosphate = aristolochene + diphosphate.
-!- The initial internal cyclization produces the monocyclic intermediate germacrene A; further cyclization and methyl transfer converts the intermediate into aristolochene. -!- While in some species germacrene A remains as an enzyme-bound intermediate, it has been shown to be a minor product of the reaction in Penicillium roqueforti (see also EC 184.108.40.206). -!- Aristolochene is the likely parent compound for a number of sesquiterpenes produced by filamentous fungi. -!- Formerly EC 220.127.116.11 and EC 18.104.22.168.
UniProtKB Entries (1)
X-ray crystal structure of aristolochene synthase from Aspergillus terreus and evolution of templates for the cyclization of farnesyl diphosphate.