CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonuclease H-like superfamily/Ribonuclease H
Functional Family Three prime repair exonuclease 1

Enzyme Information

3.1.11.2
Exodeoxyribonuclease III.
based on mapping to UniProt Q91XB0
Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.
-!- Preference for double-stranded DNA. -!- Has endonucleolytic activity near apurinic sites on DNA. -!- Similar enzyme: Haemophilus influenzae exonuclease. -!- Formerly EC 3.1.4.27.

UniProtKB Entries (1)

Q91XB0
TREX1_MOUSE
Mus musculus
Three-prime repair exonuclease 1

PDB Structure

PDB 2O4I
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of the dimeric exonuclease TREX1 in complex with DNA displays a proline-rich binding site for WW Domains.
Brucet, M., Querol-Audi, J., Serra, M., Ramirez-Espain, X., Bertlik, K., Ruiz, L., Lloberas, J., Macias, M.J., Fita, I., Celada, A.
J.Biol.Chem.