CATH Classification

Domain Context

CATH Clusters

Superfamily Aldehyde Dehydrogenase; Chain A, domain 2
Functional Family Cytosolic 10-formyltetrahydrofolate dehydrogenase

Enzyme Information

1.5.1.6
Formyltetrahydrofolate dehydrogenase.
based on mapping to UniProt P28037
10-formyltetrahydrofolate + NADP(+) + H(2)O = tetrahydrofolate + CO(2) + NADPH.

UniProtKB Entries (1)

P28037
AL1L1_RAT
Rattus norvegicus
Cytosolic 10-formyltetrahydrofolate dehydrogenase

PDB Structure

PDB 2O2Q
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structures of the carboxyl terminal domain of rat 10-formyltetrahydrofolate dehydrogenase: implications for the catalytic mechanism of aldehyde dehydrogenases.
Tsybovsky, Y., Donato, H., Krupenko, N.I., Davies, C., Krupenko, S.A.
Biochemistry