1 keywords

CATH Domain 2o21A00

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.437 Apoptosis Regulator Bcl-x
Homologous Superfamily 1.10.437.10 Blc2-like

Domain Context

CATH Clusters

Superfamily Blc2-like
Functional Family Apoptosis regulator Bcl-2

Enzyme Information

UniProtKB Entries (1)

P10415
BCL2_HUMAN
Homo sapiens
Apoptosis regulator Bcl-2

PDB Structure

PDB 2O21
External Links
Method SOLUTION NMR
Organism Escherichia
Primary Citation
Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL.
Bruncko, M., Oost, T.K., Belli, B.A., Ding, H., Joseph, M.K., Kunzer, A., Martineau, D., McClellan, W.J., Mitten, M., Ng, S.C., Nimmer, P.M., Oltersdorf, T., Park, C.M., Petros, A.M., Shoemaker, A.R., Song, X., Wang, X., Wendt, M.D., Zhang, H., Fesik, S.W., Rosenberg, S.H., Elmore, S.W.
J.Med.Chem.