CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
Functional Family

Enzyme Information

3.5.2.6
Beta-lactamase.
based on mapping to UniProt P04190
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

P04190
BLA2_BACCE
Bacillus cereus
Metallo-beta-lactamase type 2

PDB Structure

PDB 2NXA
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The Zn2 position in metallo-beta-lactamases is critical for activity: a study on chimeric metal sites on a conserved protein scaffold.
Gonzalez, J.M., Medrano Martin, F.J., Costello, A.L., Tierney, D.L., Vila, A.J.
J.Mol.Biol.