CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.58.480
Functional Family Tryptophan 2,3-dioxygenase

Enzyme Information

1.13.11.11
Tryptophan 2,3-dioxygenase.
based on mapping to UniProt Q8PDA8
L-tryptophan + O(2) = N-formyl-L-kynurenine.
-!- Catalyzes, together with EC 1.13.11.52, the first and rate-limiting step in the kynurenine pathway, the major pathway of tryptophan metabolism. -!- Specific for tryptophan as substrate, but is far more active with L-tryptophan than with D-tryptophan. -!- Formerly EC 1.11.1.4 and EC 1.13.1.12.

UniProtKB Entries (1)

Q8PDA8
T23O_XANCP
Xanthomonas campestris pv. campestris str. ATCC 33913
Tryptophan 2,3-dioxygenase

PDB Structure

PDB 2NW9
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Molecular insights into substrate recognition and catalysis by tryptophan 2,3-dioxygenase.
Forouhar, F., Anderson, J.L., Mowat, C.G., Vorobiev, S.M., Hussain, A., Abashidze, M., Bruckmann, C., Thackray, S.J., Seetharaman, J., Tucker, T., Xiao, R., Ma, L.C., Zhao, L., Acton, T.B., Montelione, G.T., Chapman, S.K., Tong, L.
Proc.Natl.Acad.Sci.Usa