CATH Domain 2nt7A00

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.190	Protein-Tyrosine Phosphatase; Chain A
	3.90.190.10	Protein tyrosine phosphatase superfamily

Superfamily	Protein tyrosine phosphatase superfamily
Functional Family	Tyrosine-protein phosphatase non-receptor type 1

3.1.3.48

Protein-tyrosine-phosphatase.

based on mapping to UniProt P18031

Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.

-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.

PTN1_HUMAN

Homo sapiens

Tyrosine-protein phosphatase non-receptor type 1

PDB	2NT7
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Probing acid replacements of thiophene PTP1B inhibitors. Wan, Z.K., Follows, B., Kirincich, S., Wilson, D., Binnun, E., Xu, W., Joseph-McCarthy, D., Wu, J., Smith, M., Zhang, Y.L., Tam, M., Erbe, D., Tam, S., Saiah, E., Lee, J. Bioorg.Med.Chem.Lett.