CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.160.20
Functional Family Drosha ribonuclease III

Enzyme Information

3.1.26.3
Ribonuclease III.
based on mapping to UniProt Q9NRR4
Endonucleolytic cleavage to 5'-phosphomonoester.
-!- An endoribonuclease that cleaves double-stranded RNA molecules. -!- The cleavage can be either a single-stranded nick or double-stranded break in the RNA, depending in part upon the degree of base-pairing in the region of the cleavage site. -!- Specificity is conferred by negative determinants, i.e., the presence of certain Watson-Crick base-pairs at specific positions that strongly inhibit cleavage. -!- RNase III is involved in both rRNA processing and mRNA processing and decay.

UniProtKB Entries (1)

Q9NRR4
RNC_HUMAN
Homo sapiens
Ribonuclease 3

PDB Structure

PDB 2NA2
External Links
Method SOLUTION NMR
Organism
Primary Citation
Towards understanding Drosha dsRBDs role in Microprocessing
Showalter, S.A., Sahu, D., Kranick, J.C., Ghosh, D.
To be Published