CATH Classification

Domain Context

CATH Clusters

Superfamily Hemopexin-like domain
Functional Family Matrix metallopeptidase 24

Enzyme Information

3.4.24.80
Membrane-type matrix metalloproteinase-1.
based on mapping to UniProt P50281
Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn-|-Leu-38. Other bonds hydrolyzed include 35-Gly-|-Ile-36 in the propeptide of collagenase 3, and 341-Asn-|-Phe- 342, 441-Asp-|-Leu-442 and 354-Gln-|-Thr-355 in the aggrecan interglobular domain.
-!- Believed to play an important role in the activation of progelatinase A at cell surfaces. -!- Belongs to peptidase family M10.

UniProtKB Entries (1)

P50281
MMP14_HUMAN
Homo sapiens
Matrix metalloproteinase-14

PDB Structure

PDB 2MQS
External Links
Method SOLUTION NMR
Organism
Primary Citation
Transient collagen triple helix binding to a key metalloproteinase in invasion and development.
Zhao, Y., Marcink, T.C., Sanganna Gari, R.R., Marsh, B.P., King, G.M., Stawikowska, R., Fields, G.B., Van Doren, S.R.
Structure