1 keywords

CATH Domain 2mpfA00

CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.60 Sandwich
Topology 2.60.120 Jelly Rolls
Homologous Superfamily 2.60.120.10 Jelly Rolls

Domain Context

CATH Clusters

Superfamily Jelly Rolls
Functional Family Putative potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

Enzyme Information

UniProtKB Entries (1)

Q9UL51
HCN2_HUMAN
Homo sapiens
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

PDB Structure

PDB 2MPF
External Links
Method SOLUTION NMR
Organism
Primary Citation
Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function.
Saponaro, A., Pauleta, S.R., Cantini, F., Matzapetakis, M., Hammann, C., Donadoni, C., Hu, L., Thiel, G., Banci, L., Santoro, B., Moroni, A.
Proc.Natl.Acad.Sci.USA