CATH Classification

Domain Context

CATH Clusters

Superfamily SH2 domain
Functional Family phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

Enzyme Information

3.1.3.86
Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase.
based on mapping to UniProt O15357
1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 3,4-diphosphate + phosphate.
-!- This enzyme hydrolyzes phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) to produce PtdIns(3,4)P(2), thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. -!- The enzyme also shows activity toward PtdIns(1,3,4,5)P(4). -!- The enzyme is involved in several signal transduction pathways in the immune system leading to an adverse range of effects. -!- Formerly EC 3.1.3.n1.

UniProtKB Entries (1)

O15357
SHIP2_HUMAN
Homo sapiens
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

PDB Structure

PDB 2MK2
External Links
Method SOLUTION NMR
Organism
Primary Citation
Solution NMR structure of N-terminal domain (SH2 domain) of human Inositol polyphosphate phosphatase-like protein 1 (INPPL1) (fragment 20-117), Northeast Structural Genomics Consortium Target HR9134A.
Yang, Y., Ramelot, T.A., Janjua, H., Xiao, R., Everett, J.K., Montelione, G.T., Kennedy, M.A.
To be Published