CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.70 | Alpha-Beta Plaits |
|
3.30.70.260 | ACT domain |
Domain Context
CATH Clusters
| Superfamily | 3.30.70.260 |
| Functional Family | Tyrosine 3-monooxygenase |
Enzyme Information
| 1.14.16.2 |
Tyrosine 3-monooxygenase.
based on mapping to UniProt P04177
L-tyrosine + tetrahydrobiopterin + O(2) = L-dopa + 4a-hydroxytetrahydrobiopterin.
-!- Activated by phosphorylation, catalyzed by EC 2.7.11.27. -!- The 4a-hydroxytetrahydrobiopterin formed can dehydrate to 6,7- dihydrobiopterin, both spontaneously and by the action of EC 4.2.1.96. -!- The 6,7-dihydrobiopterin can be enzymically reduced back to tetrahydrobiopterin, by EC 1.5.1.34, or slowly rearranges into the more stable compound 7,8-dihydrobiopterin.
|
UniProtKB Entries (1)
| P04177 |
TY3H_RAT
Rattus norvegicus
Tyrosine 3-monooxygenase
|
PDB Structure
| PDB | 2MDA |
| External Links | |
| Method | SOLUTION NMR |
| Organism | |
| Primary Citation |
The solution structure of the regulatory domain of tyrosine hydroxylase.
J.Mol.Biol.
|