CATH Classification

Domain Context

CATH Clusters

Superfamily Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Functional Family DNA replication licensing factor (Mcm)

Enzyme Information

3.6.4.12
DNA helicase.
based on mapping to UniProt Q9UXG1
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

Q9UXG1
MCM_SACS2
Saccharolobus solfataricus P2
Minichromosome maintenance protein MCM

PDB Structure

PDB 2M45
External Links
Method SOLUTION NMR
Organism
Primary Citation
Structure and regulatory role of the C-terminal winged helix domain of the archaeal minichromosome maintenance complex
Wiedemann, C., Szambowska, A., Hafner, S., Ohlenschlager, O., Guhrs, K.H., Gorlach, M.
Nucleic Acids Res.