CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.450 | Beta-Lactamase |
|
3.30.450.20 | PAS domain |
Domain Context
CATH Clusters
| Superfamily | PAS domain |
| Functional Family |
Enzyme Information
| 3.1.4.59 |
Cyclic-di-AMP phosphodiesterase.
based on mapping to UniProt A4ITV2
Cyclic di-3',5'-adenylate + H(2)O = 5'-O-phosphonoadenylyl-(3'->5')- adenosine.
-!- The enzyme, described from Gram-positive bacteria, degrades the second messenger cyclic di-3',5'-adenylate. -!- It is a membrane-bound protein that contains a cytoplasmic facing Per-Arnt-Sim (PAS) domain, a modified GGDEF domain, and a DHH/DHHA1 domain, which confers the phosphodiesterase activity. -!- Activity requires Mn(2+) and is inhibited by pApA.
|
UniProtKB Entries (1)
| A4ITV2 |
GDPP_GEOTN
Geobacillus thermodenitrificans NG80-2
Cyclic-di-AMP phosphodiesterase GdpP
|
PDB Structure
| PDB | 2M1C |
| External Links | |
| Method | SOLUTION NMR |
| Organism | |
| Primary Citation |
Solution Structure of the PAS Domain of a Thermophilic YybT Protein Homolog Reveals a Potential Ligand-binding Site.
J.Biol.Chem.
|