CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.70 | Alpha-Beta Plaits |
|
3.30.70.2350 |
Domain Context
CATH Clusters
| Superfamily | 3.30.70.2350 |
| Functional Family |
Enzyme Information
| 3.4.21.105 |
Rhomboid protease.
based on mapping to UniProt P09391
Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.
-!- These endopeptidases are multi-spanning membrane proteins. -!- Their catalytic site is embedded within the membrane and they cleave type-1 transmembrane domains. -!- Important for embryo development in Drosophila melanogaster. -!- Rhomboid is a key regulator of EGF receptor signaling and is responsible for cleaving Spitz, the main ligand of the Drosophila EGF receptor pathway. -!- Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite. -!- Belongs to peptidase family S54.
|
UniProtKB Entries (1)
| P09391 |
GLPG_ECOLI
Escherichia coli K-12
Rhomboid protease GlpG
|
PDB Structure
| PDB | 2LEP |
| External Links | |
| Method | SOLUTION NMR |
| Organism | |
| Primary Citation |
Activity-Based Protein Profiling of the Escherichia coli GlpG Rhomboid Protein Delineates the Catalytic Core.
Biochemistry
|