CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleotidyltransferases domain 2
Functional Family focal adhesion kinase 1 isoform X1

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt Q00944
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P49024
PAXI_CHICK
Gallus gallus
Paxillin

PDB Structure

PDB 2L6F
External Links
Method SOLUTION NMR
Organism
Primary Citation
NMR Solution Structure of Fat Domain of Fak Complexed with Ld2 and Ld4 Motifs of Paxillin
Bertolucci, C.M., Guibao, C., Zheng, J.
To be Published