CATH Classification

Domain Context

CATH Clusters

Superfamily Collagenase (Catalytic Domain)
Functional Family Collagenase 3

Enzyme Information

3.4.24.65
Macrophage elastase.
based on mapping to UniProt P39900
Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in the B chain of insulin.
-!- Belongs to peptidase family M10B.

UniProtKB Entries (1)

P39900
MMP12_HUMAN
Homo sapiens
Macrophage metalloelastase

PDB Structure

PDB 2KRJ
External Links
Method SOLID-STATE NMR
Organism
Primary Citation
High-resolution solid-state NMR structure of a 17.6 kDa protein.
Bertini, I., Bhaumik, A., De Paepe, G., Griffin, R.G., Lelli, M., Lewandowski, J.R., Luchinat, C.
J.Am.Chem.Soc.