CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
6 | Special |
|
6.10 | Helix non-globular |
|
6.10.130 | GTP Cyclohydrolase I; Chain A, domain 1 |
|
6.10.130.10 | Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL) |
Domain Context
CATH Clusters
| Superfamily | Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL) |
| Functional Family |
Enzyme Information
| 2.3.2.26 |
HECT-type E3 ubiquitin transferase.
based on mapping to UniProt Q05086
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)- ubiquitinyl-[acceptor protein]-L-lysine.
-!- In the first step the enzyme transfers ubiquitin from the E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) to a cysteine residue in its HECT domain (which is located in the C-terminal region), forming a thioester bond. -!- In a subsequent step the enzyme transfers the ubiquitin to an acceptor protein, resulting in the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin and the epsilon- amino group of an L-lysine residue of the acceptor protein. -!- Cf. EC 2.3.2.27 and EC 2.3.2.31.
|
UniProtKB Entries (1)
| Q05086 |
UBE3A_HUMAN
Homo sapiens
Ubiquitin-protein ligase E3A
|
PDB Structure
| PDB | 2KR1 |
| External Links | |
| Method | SOLUTION NMR |
| Organism | |
| Primary Citation |
Zn-binding AZUL domain of human ubiquitin protein ligase Ube3A.
J.Biomol.Nmr
|