CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.70.100
Functional Family Putative cadmium/zinc-transporting ATPase 3

Enzyme Information

7.2.2.12
P-type Zn(2+) transporter.
based on mapping to UniProt O64474
ATP + H(2)O + Zn(2+)(Side 1) = ADP + phosphate + Zn(2+)(Side 2).
-!- A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. -!- The enzyme, present in prokaryotes and photosynthetic eukaryotes, exports Zn(2+) and the related cations Cd(2+) and Pb(2+). -!- Formerly EC 3.6.3.5.
3.6.3.3
Cadmium-exporting ATPase.
based on mapping to UniProt O64474
ATP + H(2)O + Cd(2+)(In) = ADP + phosphate + Cd(2+)(Out).
-!- P-type ATPase that undergoes covalent phosphorylation during the transport cycle.

UniProtKB Entries (1)

O64474
HMA4_ARATH
Arabidopsis thaliana
Putative cadmium/zinc-transporting ATPase HMA4

PDB Structure

PDB 2KKH
External Links
Method SOLUTION NMR
Organism
Primary Citation
Metal binding affinities of Arabidopsis zinc and copper transporters: selectivities match the relative, but not the absolute, affinities of their amino-terminal domains
Zimmermann, M., Clarke, O., Gulbis, J.M., Keizer, D.W., Jarvis, R.S., Cobbett, C.S., Hinds, M.G., Xiao, Z., Wedd, A.G.
Biochemistry