CATH Domain 2k1qA02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Genome polyprotein

Enzyme Information

UniProtKB Entries (1)

P90191_9HEPC

Hepacivirus C

Genome polyprotein

PDB Structure

PDB	2K1Q
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism	Escherichia
Primary Citation	Binding of a noncovalent inhibitor exploiting the S' region stabilizes the hepatitis C virus NS3 protease conformation in the absence of cofactor. Gallo, M., Pennestri, M., Bottomley, M.J., Barbato, G., Eliseo, T., Paci, M., Narjes, F., De Francesco, R., Summa, V., Koch, U., Bazzo, R., Cicero, D.O. J.Mol.Biol.