CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Genome polyprotein

Enzyme Information

UniProtKB Entries (1)

P90191
P90191_9HEPC
Hepacivirus C
Genome polyprotein

PDB Structure

PDB 2K1Q
External Links
Method SOLUTION NMR
Organism Escherichia
Primary Citation
Binding of a noncovalent inhibitor exploiting the S' region stabilizes the hepatitis C virus NS3 protease conformation in the absence of cofactor.
Gallo, M., Pennestri, M., Bottomley, M.J., Barbato, G., Eliseo, T., Paci, M., Narjes, F., De Francesco, R., Summa, V., Koch, U., Bazzo, R., Cicero, D.O.
J.Mol.Biol.