CATH Classification

Domain Context

CATH Clusters

Superfamily Collagenase (Catalytic Domain)
Functional Family Collagenase 3

Enzyme Information

3.4.24.17
Stromelysin 1.
based on mapping to UniProt P08254
Preferential cleavage where P1', P2' and P3' are hydrophobic residues.
-!- Extracellular endopeptidase of vertebrate tissues. -!- Degradation of proteoglycans, fibronectin, collagen type III, IV, V and IX and activates procollagenase. -!- Belongs to peptidase family M10B.

UniProtKB Entries (1)

P08254
MMP3_HUMAN
Homo sapiens
Stromelysin-1

PDB Structure

PDB 2JT6
External Links
Method SOLUTION NMR
Organism Escherichia
Primary Citation
Matrix metalloproteinase-inhibitor interaction: the solution structure of the catalytic domain of human matrix metalloproteinase-3 with different inhibitors
Alcaraz, L.A., Banci, L., Bertini, I., Cantini, F., Donaire, A., Gonnelli, L.
J.Biol.Inorg.Chem.