CATH Domain 2jpnA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.1280	Monooxygenase
	1.20.1280.210	Uncharacterised protein UvsW.1

Domain Context

CATH Clusters

Superfamily	1.20.1280.210
Functional Family

Enzyme Information

3.6.4.12

DNA helicase.

based on mapping to UniProt P20703

ATP + H(2)O = ADP + phosphate.

-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

P20703

UVSW_BPT4

Escherichia virus T4

ATP-dependent DNA helicase uvsW

PDB Structure

PDB	2JPN
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism	Escherichia
Primary Citation	Crystallographic and NMR Analyses of UvsW and UvsW.1 from Bacteriophage T4 Kerr, I.D., Sivakolundu, S., Li, Z., Buchsbaum, J.C., Knox, L.A., Kriwacki, R., White, S.W. J.Biol.Chem.