CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.1280.210
Functional Family

Enzyme Information

3.6.4.12
DNA helicase.
based on mapping to UniProt P20703
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

P20703
UVSW_BPT4
Escherichia virus T4
ATP-dependent DNA helicase uvsW

PDB Structure

PDB 2JPN
External Links
Method SOLUTION NMR
Organism Escherichia
Primary Citation
Crystallographic and NMR Analyses of UvsW and UvsW.1 from Bacteriophage T4
Kerr, I.D., Sivakolundu, S., Li, Z., Buchsbaum, J.C., Knox, L.A., Kriwacki, R., White, S.W.
J.Biol.Chem.