CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Coagulation factor X

Enzyme Information

3.4.21.6
Coagulation factor Xa.
based on mapping to UniProt P00742
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.
-!- A blood coagulation factor formed from the proenzyme factor X by limited proteolysis. -!- Factor X is a glycoprotein composed of a heavy chain and a light chain, which are generated from a precursor protein by the excision of the tripeptide RKR and held together by one or more disulfide bonds. -!- The activated factor Xa converts prothrombin to thrombin in the presence of factor Va, Ca(2+) and phospholipids. -!- Scutelarin (EC 3.4.21.60) has similar specificity, but does not require factor Va. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P00742
FA10_HUMAN
Homo sapiens
Coagulation factor X

PDB Structure

PDB 2JKH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Cation-Pi Interactions at the Active Site of Factor Xa: Dramatic Enhancement Upon Stepwise N-Alkylation of Ammonium Ions.
Salonen, L.M., Bucher, C., Banner, D.W., Haap, W., Mary, J.L., Benz, J., Kuster, O., Seiler, P., Schweizer, W.B., Diederich, F.
Angew.Chem.Int.Ed.Engl.