CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family 23S rRNA (Uracil(1939)-C(5))-methyltransferase RlmD

Enzyme Information

2.1.1.35
tRNA (uracil(54)-C(5))-methyltransferase.
based on mapping to UniProt Q9UZR7
S-adenosyl-L-methionine + uracil(54) in tRNA = S-adenosyl-L-homocysteine + 5-methyluracil(54) in tRNA.
-!- Unlike this enzyme, EC 2.1.1.74 uses 5,10-methylenetetrahydrofolate and FADH(2) to supply the atoms for methylation of U54.

UniProtKB Entries (1)

Q9UZR7
ATRMA_PYRAB
Pyrococcus abyssi GE5
TRNA (uracil(54)-C(5))-methyltransferase

PDB Structure

PDB 2JJQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Crystal Structure of Pyrococcus Abyssi tRNA (Uracil-54, C5)-Methyltransferase Provides Insights Into its tRNA Specificity.
Walbott, H., Leulliot, N., Grosjean, H., Golinelli-Pimpaneau, B.
Nucleic Acids Res.