CATH Classification

Domain Context

CATH Clusters

Superfamily alpha/beta hydrolase
Functional Family Acetylcholinesterase

Enzyme Information

3.1.1.7
Acetylcholinesterase.
based on mapping to UniProt P21836
Acetylcholine + H(2)O = choline + acetate.
-!- Acts on a variety of acetic esters. -!- Also catalyzes transacetylations.

UniProtKB Entries (1)

P21836
ACES_MOUSE
Mus musculus
Acetylcholinesterase

PDB Structure

PDB 2JGE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structures of Acetylcholinesterase in Complex with Organophosphorus Compounds Suggest that the Acyl Pocket Modulates the Aging Reaction by Precluding the Formation of the Trigonal Bipyramidal Transition State.
Hornberg, A., Tunemalm, A.-K., Ekstrom, F.
Biochemistry