CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.12470
Functional Family 2-oxoglutarate dehydrogenase E1 component

Enzyme Information

1.2.4.2
Oxoglutarate dehydrogenase (succinyl-transferring).
based on mapping to UniProt P0AFG3
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO(2).
-!- It is a component of the multienzyme 2-oxoglutarate dehydrogenase complex in which multiple copies of it are bound to a core of molecules of EC 2.3.1.61, which also binds multiple copies of EC 1.8.1.4. -!- It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.61.

UniProtKB Entries (1)

P0AFG3
ODO1_ECOLI
Escherichia coli K-12
2-oxoglutarate dehydrogenase E1 component

PDB Structure

PDB 2JGD
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of the E1 Component of the Escherichia Coli 2-Oxoglutarate Dehydrogenase Multienzyme Complex.
Frank, R.A.W., Price, A.J., Northrop, F.D., Perham, R.N., Luisi, B.F.
J.Mol.Biol.