CATH Classification

Domain Context

CATH Clusters

Superfamily 1.50.10.10
Functional Family Cytoplasmic trehalase

Enzyme Information

3.2.1.28
Alpha,alpha-trehalase.
based on mapping to UniProt P13482
Alpha,alpha-trehalose + H(2)O = beta-D-glucose + alpha-D-glucose.
-!- The enzyme is an anomer-inverting glucosidase that catalyzes the hydrolysis of the alpha-glucosidic O-linkage of alpha,alpha- trehalose, releasing initially equimolar amounts of alpha- and beta- D-glucose. -!- It is widely distributed in microorganisms, plants, invertebrates and vertebrates.

UniProtKB Entries (1)

P13482
TREA_ECOLI
Escherichia coli K-12
Periplasmic trehalase

PDB Structure

PDB 2JG0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Molecular Basis for Trehalase Inhibition Revealed by the Structure of Trehalase in Complex with Potent Inhibitors.
Gibson, R.P., Gloster, T.M., Roberts, S., Warren, R.A.J., Storch De Gracia, I., Garcia, A., Chiara, J.L., Davies, G.J.
Angew.Chem.Int.Ed.Engl.