CATH Classification

Domain Context

CATH Clusters

Superfamily Hexapeptide repeat proteins
Functional Family Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase

Enzyme Information

2.3.1.129
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase.
based on mapping to UniProt P0A722
(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetyl-alpha-D- glucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)- N-acetyl-alpha-D-glucosamine.
-!- Involved with EC 2.4.1.182 and EC 2.7.1.130 in the biosynthesis of the phosphorylated glycolipid, lipid A, in the outer membrane of Escherichia coli.

UniProtKB Entries (1)

P0A722
LPXA_ECOLI
Escherichia coli K-12
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase

PDB Structure

PDB 2JF2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Nucleotide Substrate Recognition by Udp-N-Acetylglucosamine Acyltransferase (Lpxa) in the First Step of Lipid a Biosynthesis.
Ulaganathan, V., Buetow, L., Hunter, W.N.
J.Mol.Biol.