CATH Domain 2javA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Serine/threonine-protein kinase Nek2

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt P51955

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P51955

NEK2_HUMAN

Homo sapiens

Serine/threonine-protein kinase Nek2

PDB Structure

PDB	2JAV
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure and Regulation of the Human Nek2 Centrosomal Kinase Rellos, P., Ivins, F.J., Baxter, J.E., Pike, A.C.W., Nott, T.J., Parkinson, D.-M., Das, S., Howell, S., Fedorov, O., Shen, Q.Y., Fry, A.M., Knapp, S., Smerdon, S.J. J.Biol.Chem.