CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.60.20
Functional Family Thymidine kinase

Enzyme Information

2.7.1.21
Thymidine kinase.
based on mapping to UniProt Q0H0H6
ATP + thymidine = ADP + thymidine 5'-phosphate.
-!- Deoxyuridine can also act as acceptor. -!- dGTP can also act as donor. -!- The deoxypyrimidine kinase complex induced by Herpes simplex virus catalyzes this reaction as well as those of EC 2.7.1.114, EC 2.7.1.118 and EC 2.7.4.9. -!- Formerly EC 2.7.1.75.

UniProtKB Entries (1)

Q0H0H6
Q0H0H6_BACCE
Bacillus cereus
Thymidine kinase

PDB Structure

PDB 2JA1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Studies of Thymidine Kinases from Bacillus Anthracis and Bacillus Cereus Provide Insights Into Quaternary Structure and Conformational Changes Upon Substrate Binding
Kosinska, U., Carnrot, C., Sandrini, M.P.B., Clausen, A.R., Wang, L., Piskur, J., Eriksson, S., Eklund, H.
FEBS J.