CATH Classification

Domain Context

CATH Clusters

Superfamily DD-peptidase/beta-lactamase superfamily
Functional Family

Enzyme Information

3.4.16.4
Serine-type D-Ala-D-Ala carboxypeptidase.
based on mapping to UniProt P39844
Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.
-!- A group of bacterial enzymes, membrane-bound. -!- Inhibited by beta-lactam antibiotics, which acylate the active site serine in the enzyme. -!- Distinct from EC 3.4.17.14. -!- Belongs to peptidase families S11, S12 and S13.

UniProtKB Entries (1)

P39844
DACC_BACSU
Bacillus subtilis subsp. subtilis str. 168
D-alanyl-D-alanine carboxypeptidase DacC

PDB Structure

PDB 2J9P
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of the Bacillus subtilis penicillin-binding protein 4a, and its complex with a peptidoglycan mimetic peptide.
Sauvage, E., Duez, C., Herman, R., Kerff, F., Petrella, S., Anderson, J.W., Adediran, S.A., Pratt, R.F., Frere, J.M., Charlier, P.
J. Mol. Biol.