CATH Classification

Domain Context

CATH Clusters

Superfamily Acetylglutamate kinase-like
Functional Family Uridylate kinase

Enzyme Information

2.7.4.22
UMP kinase.
based on mapping to UniProt Q97ZE2
ATP + UMP = ADP + UDP.
-!- Strictly specific for UMP as substrate and is used by prokaryotes in the de novo synthesis of pyrimidines, in contrast to eukaryotes, which use the dual-specificity enzyme EC 2.7.4.14 for the same purpose. -!- Subject of feedback regulation, being inhibited by UTP and activated by GTP.

UniProtKB Entries (1)

Q97ZE2
PYRH_SACS2
Saccharolobus solfataricus P2
Uridylate kinase

PDB Structure

PDB 2J4L
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural and Enzymatic Investigation of the Sulfolobus Solfataricus Uridylate Kinase Shows Competitive Utp Inhibition and the Lack of GTP Stimulation
Jensen, K.S., Johansson, E., Jensen, K.F.
Biochemistry