CATH Classification

Domain Context

CATH Clusters

Superfamily Collagenase (Catalytic Domain)
Functional Family Collagenase 3

Enzyme Information

3.4.24.7
Interstitial collagenase.
based on mapping to UniProt P03956
Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at 775-Gly-|-Ile-776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue.
-!- The enzyme takes its name from substrates of the interstitial collagen group - types I, II and III, all of which are cleaved in the helical domain. -!- Alpha-macroglobulins are cleaved much more rapidly. -!- The enzyme is widely distributed in vertebrate animals. -!- Belongs to peptidase family M10B.

UniProtKB Entries (1)

P03956
MMP1_HUMAN
Homo sapiens
Interstitial collagenase

PDB Structure

PDB 2J0T
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of the Catalytic Domain of Matrix Metalloproteinase-1 in Complex with the Inhibitory Domain of Tissue Inhibitor of Metalloproteinase-1.
Iyer, S., Wei, S., Brew, K., Acharya, K.R.
J.Biol.Chem.