1 keywords

CATH Domain 2izzA01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.50 Rossmann fold
Homologous Superfamily 3.40.50.720 NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Pyrroline-5-carboxylate reductase 1

Enzyme Information

1.5.1.2
Pyrroline-5-carboxylate reductase.
based on mapping to UniProt P32322
L-proline + NAD(P)(+) = 1-pyrroline-5-carboxylate + NAD(P)H.
-!- Also reduces 1-pyrroline-3-hydroxy-5-carboxylate to L-hydroxyproline.

UniProtKB Entries (1)

P32322
P5CR1_HUMAN
Homo sapiens
Pyrroline-5-carboxylate reductase 1, mitochondrial

PDB Structure

PDB 2IZZ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of Human Pyrroline-5-Carboxylate Reductase
Pike, A.C.W., Guo, K., Kavanagh, K., Pilka, E.S., Berridge, G., Colebrook, S., Bray, J., Salah, E., Savitsky, P., Papagrigoriou, E., Turnbull, A.P., von Delft, F., Arrowsmith, C., Edwards, A., Weigelt, J., Sundstrom, M., Oppermann, U.
To be Published