CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.120.1150
Functional Family Serine/threonine-protein phosphatase 2A activator 1

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt P40454
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

P40454
PTPA1_YEAST
Saccharomyces cerevisiae S288C
Serine/threonine-protein phosphatase 2A activator 1

PDB Structure

PDB 2IXP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of the PP2A phosphatase activator: implications for its PP2A-specific PPIase activity.
Leulliot, N., Vicentini, G., Jordens, J., Quevillon-Cheruel, S., Schiltz, M., Barford, D., van Tilbeurgh, H., Goris, J.
Mol. Cell