CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family

Enzyme Information

3.2.1.49
Alpha-N-acetylgalactosaminidase.
based on mapping to UniProt A4Q8F7
Cleavage of non-reducing alpha-(1->3)-N-acetylgalactosamine residues from human blood group A and AB mucin glycoproteins, Forssman hapten and blood group A lacto series glycolipids.
-!- The human lysosomal enzyme is involved in the degradation of blood type A epitope.

UniProtKB Entries (1)

A4Q8F7
GH109_ELIME
Elizabethkingia meningoseptica
Alpha-N-acetylgalactosaminidase

PDB Structure

PDB 2IXB
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Bacterial Glycosidases for the Production of Universal Red Blood Cells.
Liu, Q.P., Sulzenbacher, G., Yuan, H., Bennett, E.P., Pietz, G., Saunders, K., Spence, J., Nudelman, E., Levery, S.B., White, T., Neveu, J.M., Lane, W.S., Bourne, Y., Olsson, M.L., Henrissat, B., Clausen, H.
Nat.Biotechnol.