CATH Classification

Domain Context

CATH Clusters

Superfamily Creatinase/prolidase N-terminal domain
Functional Family Xaa-Pro dipeptidase

Enzyme Information

3.4.13.9
Xaa-Pro dipeptidase.
based on mapping to UniProt P12955
Hydrolysis of Xaa-|-Pro dipeptides. Also acts on aminoacyl-hydroxyproline analogs. No action on Pro-|-Pro.
-!- Possibly thiol dependent. -!- Cytosolic from most animal tissues. -!- Belongs to peptidase family M24A. -!- Formerly EC 3.4.3.7.

UniProtKB Entries (1)

P12955
PEPD_HUMAN
Homo sapiens
Xaa-Pro dipeptidase

PDB Structure

PDB 2IW2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of Human Prolidase: The Molecular Basis of Pd Disease
Mueller, U., Niesen, F.H., Roske, Y., Goetz, F., Behlke, J., Buessow, K., Heinemann, U.
To be Published