CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Proto-oncogene tyrosine-protein kinase receptor Ret

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P07949
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P07949
RET_HUMAN
Homo sapiens
Proto-oncogene tyrosine-protein kinase receptor Ret

PDB Structure

PDB 2IVT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure and chemical inhibition of the RET tyrosine kinase domain.
Knowles, P.P., Murray-Rust, J., Kjaer, S., Scott, R.P., Hanrahan, S., Santoro, M., Ibanez, C.F., McDonald, N.Q.
J. Biol. Chem.