CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.420.40
Functional Family Probable tRNA N6-adenosine threonylcarbamoyltransferase

Enzyme Information

2.3.1.234
N(6)-L-threonylcarbamoyladenine synthase.
based on mapping to UniProt Q9UXT7
L-threonylcarbamoyladenylate + adenine(37) in tRNA = AMP + N(6)-L- threonylcarbamoyladenine(37) in tRNA.
-!- The enzyme is involved in the synthesis of N(6)- threonylcarbamoyladenosine(37) in tRNAs, which is found in tRNAs with the anticodon NNU, i.e. tRNA(Ile), tRNA(Thr), tRNA(Asn), tRNA(Lys), tRNA(Ser) and tRNA(Arg). -!- Formerly EC 2.6.99.4.

UniProtKB Entries (1)

Q9UXT7
KAE1_PYRAB
Pyrococcus abyssi GE5
TRNA N6-adenosine threonylcarbamoyltransferase

PDB Structure

PDB 2IVP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
An Archaeal Orthologue of the Universal Protein Kae1 is an Iron Metalloprotein which Exhibits Atypical DNA-Binding Properties and Apurinic-Endonuclease Activity in Vitro.
Hecker, A., Leulliot, N., Gadelle, D., Graille, M., Justome, A., Dorlet, P., Brochier, C., Quevillon-Cheruel, S., Le Cam, E., Van Tilbeurgh, H., Forterre, P.
Nucleic Acids Res.