CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.450.60
Functional Family Lipoxygenase

Enzyme Information

1.13.11.58
Linoleate 9S-lipoxygenase.
based on mapping to UniProt P24095
Linoleate + O(2) = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate.
-!- A common plant lipoxygenase that oxidizes linoleate and alpha- linolenate, the two most common polyunsaturated fatty acids in plants, by inserting molecular oxygen at the C(9) position with (S)- configuration. -!- The enzyme plays a physiological role during the early stages of seedling growth. -!- The enzyme from Arabidopsis thaliana shows comparable activity toward linoleate and linolenate. -!- EC 1.13.11.12 catalyzes a similar reaction at another position of these fatty acids.

UniProtKB Entries (1)

P24095
LOXX_SOYBN
Glycine max
Seed linoleate 9S-lipoxygenase

PDB Structure

PDB 2IUK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structures of Vegetative Soybean Lipoxygenase Vlx-B and Vlx-D, and Comparisons with Seed Isoforms Lox-1 and Lox-3.
Youn, B., Sellhorn, G.E., Mirchel, R.J., Gaffney, B.J., Grimes, H.D., Kang, C.
Proteins