CATH Classification

Domain Context

CATH Clusters

Superfamily Alpha carbonic anhydrase
Functional Family Carbonic anhydrase 2

Enzyme Information

4.2.1.1
Carbonic anhydrase.
based on mapping to UniProt P00915
H(2)CO(3) = CO(2) + H(2)O.
-!- The enzyme catalyzes the reversible hydration of gaseous CO(2) to carbonic acid, which spontaneously converts to hydrogencarbonate under neutral pH. -!- It is widespread and found in archaea, bacteria, and eukaryotes. -!- Three distinct classes exist, and appear to have evolved independently.

UniProtKB Entries (1)

P00915
CAH1_HUMAN
Homo sapiens
Carbonic anhydrase 1

PDB Structure

PDB 2IT4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I.
Temperini, C., Innocenti, A., Guerri, A., Scozzafava, A., Rusconi, S., Supuran, C.T.
Bioorg.Med.Chem.Lett.