CATH Classification

Domain Context

CATH Clusters

Superfamily Acid Proteases
Functional Family Beta-secretase 1

Enzyme Information

3.4.23.46
Memapsin 2.
based on mapping to UniProt P56817
Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu- Phe in the Swedish variant of Alzheimer's amyloid precursor protein.
-!- Suggested to be the major 'beta-secretase' responsible for the cleavage of the beta-amyloid precursor protein to form the amyloidogenic beta-peptide that is implicated in the pathology of Alzheimer's disease. -!- Belongs to peptidase family A1.

UniProtKB Entries (1)

P56817
BACE1_HUMAN
Homo sapiens
Beta-secretase 1

PDB Structure

PDB 2IQG
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Design, Synthesis, and Crystal Structure of Hydroxyethyl Secondary Amine-Based Peptidomimetic Inhibitors of Human beta-Secretase.
Maillard, M.C., Hom, R.K., Benson, T.E., Moon, J.B., Mamo, S., Bienkowski, M., Tomasselli, A.G., Woods, D.D., Prince, D.B., Paddock, D.J., Emmons, T.L., Tucker, J.A., Dappen, M.S., Brogley, L., Thorsett, E.D., Jewett, N., Sinha, S., John, V.
J.Med.Chem.