CATH Domain 2ip1A02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.240	Tyrosyl-Transfer RNA Synthetase
	1.10.240.10	Tyrosyl-Transfer RNA Synthetase

Domain Context

CATH Clusters

Superfamily	Tyrosyl-Transfer RNA Synthetase
Functional Family	Tryptophan--tRNA ligase, cytoplasmic

Enzyme Information

6.1.1.2

Tryptophan--tRNA ligase.

based on mapping to UniProt Q12109

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl- tRNA(Trp).

UniProtKB Entries (1)

SYWC_YEAST

Saccharomyces cerevisiae S288C

Tryptophan--tRNA ligase, cytoplasmic

PDB Structure

PDB	2IP1
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Saccharomyces
Primary Citation	Blocking S-adenosylmethionine synthesis in yeast allows selenomethionine incorporation and multiwavelength anomalous dispersion phasing. Malkowski, M.G., Quartley, E., Friedman, A.E., Babulski, J., Kon, Y., Wolfley, J., Said, M., Luft, J.R., Phizicky, E.M., DeTitta, G.T., Grayhack, E.J. Proc.Natl.Acad.Sci.Usa